- Evaluation of DNA Ploidy and Other Morphometric Parameters of Ovarian Mucinous Tumors.
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Yun Mee Kim, Sang Woo Juhng, Joo Yong Yoo, Kyu Hyuk Cho
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Korean J Pathol. 1991;25(5):397-406.
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 Abstract
- Biological behavior of malignant tumors has been assessed by morphological grading, clinical staging, and estimating other tumor markers. Recently DNA ploidy measured by flow cytometry and image analyser has been suggested as an additional useful indicator of the tumor behavior. In order to extract useful tumor cell-specific information in ovarian mucinous tumors, DNA contents and other morphologic parameters were measured by image analysis and DNA ploidy was also measured by flow cytometry. In all cases of cystadenoma, DNA diploidies were observed. In borderline malignancy, DNA diploidies were chiefly observed except one case of polyploidy. In true malignancy, DNA aneuploidies were observed except one case of polyploidy and two cases of diploidies by image analysis, and except four cases of diploides and one cas of polyploidy by flow cytometry. The statistical significance were observed in DNA ploidy pattern by image analysis. In nuclear areas, perimeters and major axis, statistical significance were not observed. These results suggest that DNA ploidy pattern are more or less independent parameter as an additional useful indicator of the histological grade of malignancy and that image analysis are better than flow cytometry in detecting DNA aneuploidy.
- Cytopathologic Observation of Primary Malignant Melanoma of the Lung: A case report.
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Yun Mee Kim, Jong Hee Nam, Min Cheol Lee, Joo Yong Yoo, Kyu Hyuk Cho
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Korean J Pathol. 1991;25(4):367-375.
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Abstract
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- The pulmonary cytology has reached a high level of accuracy.
By the examination of the sputum and/or bronchial brushings, it is now possible to make a diagnosis in 70% to 90% of patients with cancer. Primary melanoma of the lung is very rare and there have been reported about 20 cases in the world literature. We present a case of primary malignant melanoma of the lung in a 61-year-old male diagnosed by cytologic examination of sputum, bronchial brushing and aspirated pleural fluid. Histologic examination of bronchoscopic biopsy and examination of the skin and other primary sites confirmed the diagnosis.
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